Finn Harps are their first opponents.
Athlone Town begin their League of Ireland season this evening.
Ian Ryan's side welcome Finn Harps to the midlands as they aim to get off to a winning start.
Town haven't won a game in the First Division since their victory away to the Donegal outfit in May of last year.
Brendan Clarke joined the club from Galway United back in November.
He says he's looking forward to the campaign ahead:
Kick off is at 7:45pm from the Athlone Town Stadium this evening.
NHL: Galway Next In Line For Offaly In Division 1A
Offaly Hurling Legend To Feature On Laochra Gael This Evening
Midlands Boxers Named In Irish Squad For Strandja Memorial Tournament
Portlaoise Panthers Travel North To Take On Ulster University This Weekend
Andy Farrell Makes Five Changes For England Clash
Midlands Players Selected For Ireland U20's Clash With England
Crucial Weekend Awaits Midlands Sides In National Ladies Football League
F2 Star Alex Dunne Spotted In Alpine Colours At Barcelona Test
"Very Driven" Irish Winter Olympian Celebrated By Westmeath Relatives
Shane Lowry Back In Action At Genesis Invitational
Mixed Weekend In Division One For Portlaoise Panthers
Draw Made For Offaly Club Championships
We Expect To Give Everyone A Game - Ian Ryan
Defeats For Offaly And Westmeath, While Laois Secure Draw In Camogie League
Midlands Volunteers Honoured By Federation Of Irish Sport
NFL: Positive Second Half Not Enough For Offaly At Home To Cork
Gurranabraher Produce Strong Second Half To Defeat Portlaoise Panthers
Athlone Town Begin New Season With Home Win
Winning A Fitzgibbon Cup Is A Great Feeling - Adam Screeney
Offaly Narrowly Beaten By Carlow In National Ladies Football League